SARMS

SARMs (“Selective Androgen Receptor Modulators”) are synthetic compounds designed to activate the androgen receptor (AR) in a more “selective” way than traditional anabolic steroids. They’re widely sold online for physique/strength goals, but they’re not approved for bodybuilding use, and a major real-world issue is product quality/mislabelling—some “SARM” products have been found to contain different drugs or mixed ingredients. SARMs can also suppress the HPG axis (lowering natural testosterone), creating hormonal swings during use and especially after stopping.

For PFS/PSSD/PAS, SARMs are best viewed as a moderate-risk category: there aren’t as many widely shared community stories of permanent worsening as with some serotonergic drugs, but there are reports of significant flares/crashes and a few reports of longer-lasting deterioration. The bigger practical issue is that SARMs directly manipulate androgen receptor signaling and can cause unpredictable rebound effects, and with the contamination/mislabelling risk, you often don’t even know what you took. Bottom line: even if permanent crashes aren’t the most common story, SARMs are generally not worth the risk for already-sensitized individuals.

Crash Anecdotes:

https://www.reddit.com/r/PSSD/comments/miv16g/has_anyone_who_had_pssd_ever_try_sarms/

https://www.reddit.com/r/FinasterideSyndrome/comments/1cedacm/sarms_rad140/

My Personal Risk Ranking:

Moderate Risk of Permanent Worsening (for PFS/PSSD/PAS):

If you currently have PFS/PSSD/PAS, SARMs may carry a moderate risk of worsening symptoms—sometimes in a lasting way—because they directly manipulate androgen receptor signaling and can cause significant hormonal swings during use and after stopping. While there aren’t as many widely shared permanent-worsening stories as with some serotonergic drugs, there are reports of flares/crashes (and a few longer-lasting deteriorations), and the added risk of mislabeled/contaminated products makes outcomes unpredictable. For most people, SARMs are best avoided, especially during stabilization